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Una sonrisa no cuesta dinero
Translations available in: Spanish (original) | French | Italian | German | Portuguese | English | Swedish | Russian | Dutch | Arabic

A smile does not cost money
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The best time of a human being is the childhood… all we do it sincerely, with brotherhood… and the best thing, US REIMOS MUCH! Being an adult one now I see the smile of a boy or a girl and feel as the pain dissipates… a smile moves away the fog of the heart. A love smile subjugates to you, insists to you to continue living… Y cuando veo la sonrisa de mi sobrina, me dan ganas de reir, de llorar, de amar y ser amado.

A smile does not cost money, gives a little joy to which plus it needs it… SMILE!

March 9, 2008 | 9:58 PM Comments  0 comments

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Anti-HIV gel trial fails
Related to country: Panama

Translations available in: English (original) | French | Spanish | Italian | German | Portuguese | Swedish | Russian | Dutch | Arabic

Carraguard, the first anti-HIV microbicide to make it to the end of phase III clinical trials has failed to prevent transmission of HIV.

The seaweed-derived vaginal gel microbicide was tested in 6,202 women in South Africa. Half the women were given Carraguard gel, and the other half received a placebo gel. They were all also given given condoms. Over the course of the trial, the researchers recorded 134 new infections in the Carraguard group and 151 in the placebo group, but the difference was not statistically significant.

“The results are the results. The gel doesn’t work,” says Alana de Kock, principal investigator for the portion of the trial run from the University of Cape Town. The trial was organised and run by the Population Council, a non-profit reproductive-health research organization based in New York.

The results add to the round of bad news associated with microbicide gels, of which five have recently entered clinical trials. Two of those trials have been stopped prematurely. The trial of a compound called cellulose sulphate, run by CONRAD, a reproductive health organization based in Arlington, Virginia, was stopped last year after early results indicated a slight increase in the chance of infection in the group using the gel. And the trial of a compound called C31G was stopped early in 2004 because the incidence of HIV in the test community was too low for a trial to be able to detect any effect of the treatment.

Two trials remain, both with different active ingredients: PRO 2000, developed by Indevus Pharmaceuticals in Lexington, Massachusetts; and BufferGel, under development by ReProtect in Baltimore, Maryland. One part of the PRO 2000 trial has also been stopped, after initial work suggested it would not have a significant effect.

Early promise
Carraguard, based on the natural compound carrgeenan, showed promising results in early lab-based and animal-based trials. “Based on the basic science in the lab it was a very, very positive product,” says de Kock. But, she adds, “those are very controlled environments”.

Working with humans, especially in the area of sexual health, offers many more challenges. “The bottom line is it hasn’t worked in real women, in the real world,” she says.

Despite the failure of the trial, the Population Council was commended by the South African health minister for the care taken of the women on the trial. de Kock says it is important that the trial ran to completion, and showed that Carraguard was safe for long-term use. “It’s important to prove you can do a trial successfully in a community,” she says.

The scientists from the Population Council are now working on a combined product (PC815), which contains both Carraguard and an antiretroviral. The antiretroviral drug, called MIV-150, was shown to be ineffective as an oral drug because it was poorly absorbed by the body. But this property is useful in a vaginal gel as it keeps the drug on the surface and at the point of possible infection, says Melissa May, a spokesperson for the Population Council. This product is now in early safety trials with people.

It is still worth pursuing microbicides as an HIV preventative, says Sheena McCormack, from the UK’s Medical Research Council, who is involved in the PRO2000 trial. Even though the Carraguard trial could not show a statistical significance, the data show that the microbicide had a small effect. “It’s a signal in the right direction,” says McCormack. “As a scientist I’m very encouraged by that.”

February 20, 2008 | 8:58 PM Comments  0 comments

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TRES CONSEJOS
Related to country: Panama

Translations available in: Spanish (original) | French | Italian | German | Portuguese | English | Swedish | Russian | Dutch | Arabic

THREE ADVICE
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A pair of just married, was very poor and lived on the favors of a pueblito of the interior. A day, the husband did the following proposal to him to his wife: “Loved I am going to leave the house. I am going to travel well far, to look for a use and to work until having conditions to return and darte one more a more comfortable and worthy life. I do not know how long I am going to be far; to only I request a thing you: that you wait for to me and while I this distant spot, you are faithful to me, because I will be to you faithful to you. “

Thus, being young still, it on foot walked many days, until finding a landowner who was needing somebody to help it in his property. The young person arrived and she was offered to work and she was accepted. It requested to make a deal with its head, who was also accepted. The pact was the following one: “Déjeme to work by the time that I want and when I find that I must go to me, the gentleman releases to me of my obligations. I do not want to receive my wage. I ask to him the gentleman who places it in an account of savings until the day in which he goes to me. The day that I leave, you. it will give the money me that I have won. “

Being both in agreement, that young person worked during 20 years, without vacations and rest. After twenty years, one approached its pattern and it said to him: “Pattern, I want my money, because I want to return to my house.” The pattern responded to him: “Very well, we made a pact and I am going to fulfill it. Only that before I want hacerte a proposal, is well. I give your money you and you go away, or I give three advice you and I do not give the money you and you go away. If I give the money you, I do not give the advice vice versa you and. Veto to your quarter, piénsalo and later it give the answer me. “

He thought during two days, looked for the pattern and he said to him: “I LOVE THE THREE ADVICE.” The pattern remembered to him: "Si te doy los consejos, no te doy el dinero." Y el empleado respondió: “I love the advice.” The then pattern advised to him:

1. “YOU NEVER TAKE SHORT CUTS IN YOUR LIFE. Shorter ways and strangers you can cost the life.

2. YOU ARE NEVER PECULIAR WHAT BADLY IT REPRESENTS, because the curiosity by badly can be fatal.

3 NEVER YOU MAKE DECISIONS AT MOMENTS FROM HATRED AND PAIN, because you can arrepentirte too much behind schedule.

After giving the advice him, the pattern said to him to the young person, that no longer she was it as much: “HERE YOU HAVE THREE BREADS: two to eat during in trip and third are for eating with their wife, when you arrive at your house ". The man, then, followed his way of return, twenty years far from his house and their wife who he as much loved.

After the first day of trip, it found a person who greeted it and she asked to him: “ For where you go” It responded to him, “I go far distant for a way that is more than twenty days of long walk by this highway.” The person said to him then: “Young, this way is very long. I know a short cut with which you will arrive in few days ". The young person, contentment, began to walk by the short cut, when she remembered the first advice. Then, it returned to follow by the normal way. Days later, it knew that the short cut took to an ambush.

After some days of trip, and tired to the end, it found a pension to the side of the highway, where to be able to stay itself. The tariff per day paid and, after taking a bath, it lay down to sleep. At daybreak one rose scared with a frightful shout. One rose of a jump and one went until the door to go to where it listened to the shout. When it was opening the door, one remembered the second advice. It returned and one lay down to sleep.

The dawn, after taking coffee, the owner of the inn asked to him but he had listened to the shout and he answered to him that yes he had listened to it. The owner of the inn asked to him: “ And did not feel curiosity”. Él le contestó que no. To which the owner responded to him: “You he is the first guest who leaves alive here, because my only son has madness crisis; it shouts during the night and when the guest leaves, it kills it and it buries it in the quintal ". The young person followed his long day, anxious to arrive at his house.

After many days and nights of long walk, already the dusk, it saw between the trees smoke leaving the chimney of its small house. It walked and it saw between the shrubs the silhouette of its wife. It was growing dark, but it reached to see that it was not single. He walked a little more and it saw that it had on her lap, a man to whom was caressing the hair.
When it saw that scene, its heart filled of hatred and bitterness and decided to run to the encounter of both and killing them without mercy. It breathed deep, hurried its steps, when the third advice remembered. Then it was stopped and it reflected and it decided to sleep same that night there and on the following day to make a decision.

To the dawn, already with the cold head, he said: “I AM NOT GOING TO KILL MY WIFE. I am going to return with my pattern and to request to him that it accepts me of return, only that before, I mean to him to my wife who always I was to him faithful. “One went to the door of the house and touched. When the wife opened the door to him and she recognized it, she was hung of its neck and she embraced it affectionately. He tried to clear it to it of above, but he did not obtain it. Then, with tears in the eyes it said to him: “I was to you faithful and your you betrayed to me…” It stampede responded to him, “ How? I never betrayed to you. I hoped to you during twenty years ". He then asked to him, “ And who was that man who you caressed yesterday in the evening? And she answered to him, “THAT MAN IS OUR SON. When you were yourself, I discovered that she was pregnant. Hoy él tiene veinte años de edad".

Then, the husband entered, knew, embraced his son and he told all its history them, while her wife prepared the supper. They seated to eat the last bread together. AFTER the GRATEFULNESS ORATION, WITH EMOTION TEARS, it divided the bread and when opening it, was all its money: the payment of its twenty years of dedication

==================================

Often we think that the short cuts “burn stages” and they help us to arrive more express, which not always is truth.

Often we are peculiar; we want to know of things that neither give respect us nor bring nothing to us of good.

Other times we reacted moved by the impulse, at moments of rage, and later delayed we regreted.

I hope that you, as well as I, you do not forget these advice, you also do not forget TO TRUST (although you have many reasons to distrust).

February 19, 2008 | 8:19 PM Comments  0 comments





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